Product Name	FBXO9
Chinese Name	F-box蛋白9抗体
Alias	Cross-immune reaction antigen 1; dJ341E18.2; DKFZp434C0118; F-box only protein 9; Fbp24; FBX9; FBX9_HUMAN; Fbxo9; KIAA0936; NY REN 57; OTTHUMP00000016628; OTTHUMP00000016629; OTTHUMP00000214588; Renal carcinoma antigen NY-REN-57; VCIA1.
Research Area	Cell biology  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, Chimpanzee, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FBX09: 301-400/447
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]. Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1. Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2. Subcellular Location: Cytoplasm. Similarity: Contains 1 F-box domain. Contains 1 TPR repeat. SWISS: Q9UK97 Gene ID: 26268 Database links: Entrez Gene: 421895 Chicken Entrez Gene: 511798 Cow Entrez Gene: 26268 Human Entrez Gene: 71538 Mouse Entrez Gene: 300849 Rat Entrez Gene: 325469 Zebrafish Omim: 609091 Human SwissProt: Q3ZBT2 Cow SwissProt: Q9UK97 Human SwissProt: Q8BK06 Mouse SwissProt: Q5U2X1 Rat SwissProt: Q6DG26 Zebrafish SwissProt: Q6P3K3 Zebrafish

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