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Product Name Fibulin 2 Chinese Name 纤连蛋白2抗体 Alias Fibulin-2; Fbln2; FBLN2_HUMAN; FIBL-2; Fibulin-2; OTTHUMP00000216670; OTTHUMP00000216671; OTTHUMP00000216672. Research Area Tumour Cell biology Neurobiology Extracellular matrix Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 124kDa Cellular localization Extracellular matrix Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Fibulin 2: 501-600/1184 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Fibulin-1 and Fibulin-2 associate with Fibronectin and other extracellular matrix proteins. In bone marrow, Fibulin-1 and Fibulin-2 bind to Fibronectin in the adherent layer. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and as an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. The mobility of cancer cells may be inhibited with increasing exposure to Fibulin-1. Fibulin-2 binds to the lectin domains of extracellular matrix proteins aggrecan, versican and brevican. Fibulin-2 is abundantly expressed in heart, placenta and ovarian tissue, where it localizes to basement membranes and connective tissue compartments. In mice, differential Fibulin-2 gene expression correlates with the early phase of diabetic kidneys and glomerulosclerosis. The gene encoding human Fibulin-2 maps to chromosome 3p25.1.
Function:
Its binding to fibronectin and some other ligands is calcium dependent.
Subunit:
Homotrimer; disulfide-linked. Interacts with LAMA2 (By similarity).
Subcellular Location:
Secreted; extracellular space; extracellular matrix.
Tissue Specificity:
Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary.
Post-translational modifications:
O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348.
Similarity:
Belongs to the fibulin family.
Contains 3 anaphylatoxin-like domains.
Contains 11 EGF-like domains.
SWISS:
P98095
Gene ID:
2199
Database links:Entrez Gene: 2199 Human
Entrez Gene: 14115 Mouse
Omim: 135821 Human
SwissProt: P98095 Human
SwissProt: P37889 Mouse
Unigene: 198862 Human
Unigene: 249146 Mouse
Unigene: 410235 Mouse
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