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Product Name FCGRT Chinese Name IgG-Fc片断受体Transporterα抗体 Alias IgG receptor FcRn large subunit p51; Fc fragment of IgG, receptor transporter, alpha; FCGRT; FcRn alpha chain; FCRN; FCRN, alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor, intestinal, heavy chain; Neonatal Fc receptor; FCGRN_HUMAN. literatures Specific References (1) | SL13151R has been referenced in 1 publications.[IF=1.64] Zhang, Wang-Dong, et al. "Localization of neonatal Fc receptor for IgG in aggregated lymphoid nodules area in abomasum of Bactrian camels (Camelus bactrianus) of different ages." BMC Veterinary Research 12.1 (2016): 237. IHC-P ; Others.Research Area Cell biology immunology The cell membrane受体 vascular endothelial cell Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Dog, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3μg/Test ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 37kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FCGRT/FcRn: 51-150/365 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins.
Function:
Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.
Subunit:
FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity).
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the immunoglobulin superfamily.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
SWISS:
P55899
Gene ID:
2217
Database links:Entrez Gene: 2217 Human
Omim: 601437 Human
SwissProt: P55899 Human
Unigene: 111903 Human
Product Picture Sample: bladder (Mouse)Lysate at 40 ug
Primary: Anti-FCGRT(SL13151R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38kD
Observed band size: 38 kD
Blank control(blue): U-87MG(fixed with 2% paraformaldehyde (10 min)).
Primary Antibody:Rabbit AntiFCGRT antibody(SL13151R), Dilution: 3μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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