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Product Name EFS Chinese Name 对接蛋白EFS抗体 Alias CAS3; CASS3; EFS1; EFS2; Embryonal Fyn associated substrate; HEFS; SIN; EFS_HUMAN. Research Area Cell biology Cell adhesion molecule Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 59kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human EFS: 201-300/561 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail EFS is a docking protein which plays a pivotal role for cell adhesion-related intracellular tyrosine kinase signaling, where it may serve as an activator of SRC and is known to interat with the SH3 domain of FYN and with CRK, SRC, and YES.
Function:
Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES (By similarity).
Subcellular Location:
Cytoplasm
Tissue Specificity:
The protein has been detected in lung and placenta.
Post-translational modifications:
Phosphorylated on multiple tyrosine residues. Phosphorylated on tyrosines by FYN and SRC (By similarity).
Similarity:
Belongs to the CAS family.
Contains 1 SH3 domain.
SWISS:
O43281
Gene ID:
10278
Database links:Entrez Gene: 10278 Human
Entrez Gene: 13644 Mouse
Omim: 609906 Human
SwissProt: O43281 Human
SwissProt: Q64355 Mouse
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