Product Name	ECHDC2
Chinese Name	烯酰辅酶A水合酶含结构域蛋白2抗体
Alias	1300017C12Rik; 2610009M20Rik; D4Ertd765e; Enoyl Coenzyme A hydratase domain containing 2; FLJ10948; Enoyl-CoA hydratase domain-containing protein 2; RGD1308525; RP23-379K6.3; ECHD2_HUMAN.
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Zebrafish, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ECHDC2: 153-260/292
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ECHDC2 is a 292 amino acid mitochondrial protein that exists as two isoforms which are produced by alternative splicing events. The gene encoding ECHDC2 maps to chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 encodes a large number of disease-associated proteins, including Lamin A which, when expressed abnormally, can build up in the nucleus and cause nuclear blebs, a characteristic of the rare aging disease Hutchinson-Gilford progeria. Additionally, genes that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinsons Disease, Gaucher disease, schizophrenia and Usher syndrome are all located on chromosome 1. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. Function: ECHDC2 belongs to the enoyl-CoA hydratase/isomerase family. There are two named isforms. Subcellular Location: Mitochondrion (Potential). Similarity: Belongs to the enoyl-CoA hydratase/isomerase family. SWISS: Q86YB7 Gene ID: 55268 Database links: Entrez Gene: 55268 Human Entrez Gene: 52430 Mouse Entrez Gene: 298381 Rat SwissProt: Q86YB7 Human SwissProt: Q3TLP5 Mouse

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