Product Name	EAAT4
Chinese Name	胶质细胞谷氨酸运载蛋白4抗体
Alias	Excitatory amino acid transporter 4; SLC1A6; High affinity neuronal glutamate transporter; MGC33092; MGC43671; Sodium dependent glutamate/aspartate transporter; Solute carrier family 1 (high affinity aspartate/glutamate transporter) member 6; Solute carrier family 1 member 6;
Research Area	Cell biology  Chromatin and nuclear signals  transcriptional regulatory factor  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	62kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EAAT4: 151-250/564 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid neurotransmitters. EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities. EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT family, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering. Function: EAAT4 is expressed predominantly in the cerebellum (Purkinje cells) and weakly in the forebrain, where it transports L-glutamate, L-aspartate and D-aspartate, acting as a symport by cotransporting sodium. EAAT4 may function as a combined transporter and inhibitory glutamate receptor and also functions as an anion-selective ion channel. Subcellular Location: Membrane; multi-pass membrane protein. Tissue Specificity: Brain. Expressed densely and selectively incell bodies of Purkinje cells. Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter(TC 2.A.23) family. SLC1A6 subfamily. SWISS: P48664 Gene ID: 6511 Database links: Entrez Gene: 6511 Human Entrez Gene: 20513 Mouse Entrez Gene: 84012 Rat Omim: 600637 Human SwissProt: P48664 Human SwissProt: O35544 Mouse SwissProt: O35921 Rat Unigene: 10827 Rat

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