Product Name	DGAT2
Chinese Name	甘油二酯酰基转移酶2抗体
Alias	DGAT2_HUMAN; Diacylglycerol O acyltransferase like protein 2; Diacylglycerol O-acyltransferase 2; Diacylglycerol O-acyltransferase homolog 2 (mouse); Diacylglycerol O-acyltransferase homolog 2; Diacylglycerol O-acyltransferase-like protein 2 isoform 1; Diglyceride acyltransferase 2; DKFZp686A15125; GS1999full; HMFN1045.
literatures	Specific References  (4)     |     SL12998R has been referenced in 4 publications. [IF=20.773] van Rijn JM et al. Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency. Gastroenterology. 2018 Jul;155(1):130-143.e15.  WB ;  Human.   PubMed:29604290 [IF=6.268] Jin, Yi. et al. Glutathione S-transferase Mu 2 inhibits hepatic steatosis via ASK1 suppression. COMMUN BIOL. Commun Biol. 2022 Apr;5(1):1-12  IF ;  Human.   PubMed:35388144 [IF=4.743] van Rijn JM et al. DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells. J Lipid Res. 2019 Jul 17. pii: jlr.M094201.  WB ;  Human.   PubMed:31315900 [IF=2.559] Wang X et al. ER stress mediated degradation of diacylglycerol acyltransferase impairs mitochondrial functions in TMCO1 deficient cells. Biochem Biophys Res Commun. 2019 May 14;512(4):914-920.  WB ;  Human.   PubMed:30929916
Research Area	Tumour  Cardiovascular  Cell biology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	44kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DGAT2: 251-360/388
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Glucose and insulin are anabolic signals which upregulate the transcriptions of a series of lipogenic enzymes to convert excess carbohydrate into triglycerides for efficient energy storage. Acyl-coenzyme A:diacylglycerol acyltransferase, also known as DGAT1 and ARGP1, is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT1 catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT1 plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism, such as intestinal fat absorption, lipoprotein assembly, adipose tissue form-ation and lactation. DGAT2, which has no homology to DGAT1, differs from DGAT1 in that its activity has been shown to be inhibited by MgCl in an in vitro assay. DGAT2 is expressed primarily in liver and white adipose tissue, which suggests that it plays an important role in mammalian triglyceride metabolism. Function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. Subunit: Forms multimeric complexes consisting of several DGAT2 subunits (By similarity). Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. Similarity: Belongs to the diacylglycerol acyltransferase family. SWISS: Q96PD7 Gene ID: 84649 Database links: Entrez Gene: 404129 Cow Entrez Gene: 84649 Human Entrez Gene: 67800 Mouse Entrez Gene: 252900 Rat SwissProt: Q70VZ8 Cow SwissProt: Q96PD7 Human SwissProt: Q9DCV3 Mouse SwissProt: Q5FVP8 Rat

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