Product Name	Dermcidin
Chinese Name	抗菌蛋白DCD抗体
Alias	AIDD; DCD 1; dcd; DCD-1; DCD_HUMAN; DSEP; HCAP; PIF; Preproteolysin; Dermcidin.
Research Area	Cell biology  Bacteria and viruses  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	11kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Dermcidin/DCD: 63-109/110
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Antimicrobial peptides participate in the innate response, which may provide a barrier for protection against infection. The Dermcidin gene encodes an antimicrobial peptide DCD-1, which is constitutively expressed in sweat glands, secreted into the sweat, and transported to the epidermal surface. DCD-1 displays antimicrobial activity in response to a variety of pathogenic microorganisms. Overexpression of Dermcidin in breast cancers promotes cell growth and survival, and is coupled with a focal copy number gain of its locus on human chromosome 12q13.2. Function: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG. Subcellular Location: Secreted. Tissue Specificity: Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml. SWISS: P81605 Gene ID: 117159 Database links: Entrez Gene: 117159 Human Omim: 606634 Human SwissProt: P81605 Human Unigene: 350570 Human 人源性多肽Dermcidin(DCD)是最近从人体汗液中分离出来的一种天然活性多肽,其编码基因dermcidin最初被认为在汗腺中特异性表达,并且与其他已知的编码基因没有同源性。DCD在外泌汗腺中组成性表达并分泌到汗液中,其衍生物DCD-1L和DCD-1在较广的pH范围和高盐浓度下具有抗部分细菌和真菌的活性。经证实,以前在人类神经细胞中发现的一种存活促进肽以及人体内与一种鼠恶病质因子同源的多肽均属于DCD衍生物。最新研究发现dermcidin基因在人乳腺癌等Tumour细胞及肝细胞中可能作为潜在的致癌基因而存在。不仅如此,人们在人类胎盘组织中也发现了dermcidin基因的表达并分离出了DCD。所以,DCD可能作为多功能的活性多肽在Tumour发生及人体天然免疫系统疾病、神经系统疾病、妊娠相关疾病的病理生理过程中发挥作用。在感染性疾病和炎症上将来有着广泛应用的可能。

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