Product Name	TAF6
Chinese Name	转录起始因子TFIID亚基6抗体
Alias	E 70/85kD; TAF 6; TAF2E; TAF6 RNA polymerase II TATA box binding protein (TBP) associated factor 80 kD; TAF6 RNA polymerase II, TATA box binding protein associated factor,80kDa; TAFII 70; TAFII80; TATA box binding protein (TBP) associated factor RNA polymerase II E 70/85kD; TATA box binding protein (TBP) associated factor, RNA polymerase II,; TBP associated factor 6; Transcription initiation factor TFIID 70 kDa subunit; Transcription initiation factor TFIID subunit 6.
literatures	Specific References  (1)     |     SL12967R has been referenced in 1 publications. [IF=0] Wang J et al. Proteomics and molecular network analyses reveal that the interaction between the TAT–DCF1 peptide and TAF6 induces an antitumor effect in glioma cells. Mol Omics. 2020 Jan 3.  ICF ;  Human.   PubMed:31899468
Research Area	transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	73kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TAF6: 111-210/677
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Subunit: TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex. Subcellular Location: Nuclear. Similarity: Belongs to the TAF6 family. SWISS: P49848 Gene ID: 6878 Database links: Entrez Gene: 505638 Cow Entrez Gene: 6878 Human Entrez Gene: 21343 Mouse Entrez Gene: 288533 Rat Entrez Gene: 447818 Zebrafish Omim: 602955 Human SwissProt: Q58DG7 Cow SwissProt: P49848 Human SwissProt: Q62311 Mouse SwissProt: Q498R0 Rat SwissProt: Q63801 Rat Unigene: 489309 Human

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