Product Name	phospho-alpha Adducin (Thr445)
Chinese Name	磷酸化内收蛋白抗体
Alias	Adducin (phospho T445); p-Adducin (phospho T445); ADD1; ADDA; Adducin 1 (alpha); Adducin 1; Alpha adducin; ADDA_HUMAN.
Product Type	Phosphorylated anti
Research Area	Tumour  Cell biology  Signal transduction  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	80kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide derived from human alpha Adducin around the phosphorylation site of Thr445: EK(p-T)RW
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Subunit: Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Subcellular Location: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit. Similarity: Belongs to the aldolase class II family. Adducin subfamily. SWISS: P35611 Gene ID: 118 Database links: Entrez Gene: 118 Human Entrez Gene: 11518 Mouse Entrez Gene: 24170 Rat Omim: 102680 Human SwissProt: P35611 Human SwissProt: Q9QYC0 Mouse SwissProt: Q63028 Rat Unigene: 183706 Human Unigene: 289106 Mouse Unigene: 5788 Rat

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