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Rabbit Anti-phospho-ZFP36L1 (Ser92)antibody
Rabbit Anti-phospho-ZFP36L1 (Ser92)antibody
butyrate response factor 1 (phospho S92); ZFP36L1 (phospho S92); Berg36; BRF1; Butyrate response factor 1(phospho S334); C3H1 type-like 1; cMG1; Early response factor Berg36; EGF response factor 1; EGF-response factor 1; ERF 1; ERF-1; ERF1; Protein TIS11B
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  • NO.:SL12902R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep,)
    Applications:ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
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Details

Product Name phospho-ZFP36L1 (Ser92)
Chinese Name 磷酸化丁酸盐反应因子1抗体
Alias butyrate response factor 1 (phospho S92); ZFP36L1 (phospho S92); Berg36; BRF1; Butyrate response factor 1(phospho S334); C3H1 type-like 1; cMG1; Early response factor Berg36; EGF response factor 1; EGF-response factor 1; ERF 1; ERF-1; ERF1; Protein TIS11B; RNF162B; TIS11B; TISB_HUMAN; ZFP36L1; Zinc finger protein 36 C3H type like 1; zinc finger protein C3H type 36 like 1; BERG36; Zinc finger protein 36, C3H1 type-like 1.  
Product Type Phosphorylated anti 
Research Area Cell biology  Developmental biology  Signal transduction  Stem cells  Growth factors and hormones  transcriptional regulatory factor  Zinc finger protein  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 36kDa
Cellular localization The nucleus 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthesised phosphopeptide derived from human ZFP36L1 around the phosphorylation site of Ser92: SF(p-S)EG 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail EGF response factor 1 is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. TIS11B, a relative of TTP, localizes to the nucleus and may function as a transcription factor involved in regulating the growth factor response. It is an evolutionarily conserved protein containing two C3H1-type zinc fingers and a repeating cys-his motif. TIS11B is an mRNA binding protein and is known to interact with the 3’-untranslated region of VEGF mRNA, thereby decreasing its stability. This suggests that TIS11B is a potential target in antiangiogenic therapy. In addition, TIS11B may also be an important regulator of myogenesis, as its expression is upregulated during murine myoblast differentiation.

Function:
Butyrate response factor 1 is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating Cys-His motif. This putative nuclear transcription factor probably functions in regulating the response to growth factors.

Subcellular Location:
Nuclear.

Similarity:
Contains 2 C3H1-type zinc fingers.

SWISS:
Q07352

Gene ID:
677

Database links:

Entrez Gene: 400223 Human

Entrez Gene: 677 Human

Entrez Gene: 12192 Mouse

Entrez Gene: 29344 Rat

Omim: 601064 Human

SwissProt: Q07352 Human

SwissProt: P23950 Mouse

SwissProt: P17431 Rat

Unigene: 707091 Human

Unigene: 85155 Human

Unigene: 235132 Mouse

Unigene: 6142 Rat



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