Product Name	TCF7L1
Chinese Name	转录因子7样蛋白1抗体
Alias	bHLHb21; HMG box transcription factor 3; HMG box transcription factor; OTTMUSP00000023419; T cell factor 3; TCF 3; TCF-3; TCF3; Tcf7l1; TF7L1_HUMAN; Transcription factor 7 like 1 (T-cell specific, HMG-box); Transcription factor 7 like 1; Transcription factor 7-like 1.
Research Area	Stem cells  transcriptional regulatory factor  lymphocyte  t-lymphocyte  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Cow, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	63kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TCF7L1: 51-150/588
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010] Function: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. Subcellular Location: Nucleus. Tissue Specificity: Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium. Similarity: Belongs to the TCF/LEF family. Contains 1 HMG box DNA-binding domain. SWISS: Q9HCS4 Gene ID: 83439 Database links: Entrez Gene: 83439 Human Entrez Gene: 21415 Mouse Entrez Gene: 312451 Rat Omim: 604652 Human SwissProt: Q9HCS4 Human SwissProt: Q9Z1J1 Mouse Unigene: 516297 Human Unigene: 440067 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human skin); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TCF7L1) Polyclonal Antibody, Unconjugated (SL12891R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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