Product Name	BRD2
Chinese Name	BRD2蛋白抗体
Alias	Bromodomain-containing protein 2; KIAA9001; RING3; O27.1.1; Really interesting new gene 3 protein; BRD2_HUMAN;
Research Area	Signal transduction  Kinases and Phosphatases  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	88kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BRD2: 301-400/801
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010] Function: May play a role in spermatogenesis or folliculogenesis. Subunit: Homodimer. Interacts with E2F1 and with histone H4acetylated at 'Lys-13'. Subcellular Location: Nucleus. Similarity: Contains 2 bromo domains. Contains 1 ET domain. SWISS: P25440 Gene ID: 6046 Database links: Entrez Gene: 6046 Human Entrez Gene: 14312 Mouse Entrez Gene: 294276 Rat SwissProt: P25440 Human SwissProt: Q7JJ13 Mouse SwissProt: Q6MGA9 Rat
Product Picture	Sample: Lane 1: Molt-4 (Human) Cell Lysate at 30 ug Lane 2: MDA-MB-231 (Human) Cell Lysate at 30 ug Primary: Anti-BRD2 (SL12888R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 110-115 kD Observed band size: 130 kD

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