Product Name	BOP1
Chinese Name	核糖体合成蛋白BOP1抗体
Alias	AU020183; AW146150; Block of proliferation 1; Block of proliferation 1 protein; Bop1; Bop1 block of proliferation 1; BOP1_HUMAN; D18861; Erb1p; Kiaa0124; MGC109114; mKIAA0124; Ribosome biogenesis protein BOP1.
literatures	Specific References  (1)     |     SL12877R has been referenced in 1 publications. [IF=5.076] Jia Fangyuan. et al. BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis. Oxid Med Cell Longev. 2021;2021:5986260  WB,IF,IHC ;  Human, Rat.   PubMed:33510838
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	84kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BOP1: 201-300/746
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis. Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Subunit: Component of the PeBoW complex, composed of BOP1, PES1and WDR12. Within the PeBoW complex BOP1 interacts directly withPES1 and WDR12. The PeBoW complex also associates with the 66Spre-ribosome. Subcellular Location: Nucleus Similarity: Belongs to the WD repeat BOP1/ERB1 family. Contains 7 WD repeats. SWISS: Q14137 Gene ID: 23246 Database links: Entrez Gene: 23246 Human Entrez Gene: 12181 Mouse Entrez Gene: 300050 Rat Omim: 610596 Human SwissProt: Q14137 Human SwissProt: P97452 Mouse SwissProt: Q562C2 Rat Unigene: 645279 Human Unigene: 4283 Mouse Unigene: 101388 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (BOP1) Polyclonal Antibody, Unconjugated (SL12877R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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