Product Name	Plakophilin 4
Chinese Name	桥粒斑菲素蛋白4抗体
Alias	Catenin 4 ; Catenin4 ; FLJ31261 ; FLJ42243 ; p0071 ; PKP 4 ; PKP4 ; PKP4_HUMAN ; Plakophilin-4 ; Plakophilin4.
Research Area	Cell biology  Developmental biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	132kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Plakophilin 4: 1101-1192/1192
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015] Function: May play a role in junctional plaques. Subcellular Location: Cell junction > desmosome. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the beta-catenin family. Contains 9 ARM repeats. SWISS: Q99569 Gene ID: 8502 Database links: Entrez Gene: 281406 Cow Entrez Gene: 8502 Human Entrez Gene: 227937 Mouse Entrez Gene: 295625 Rat Omim: 604276 Human SwissProt: Q99569 Human SwissProt: Q68FH0 Mouse Unigene: 407580 Human Unigene: 260938 Mouse
Product Picture	Sample: Hela(Human) Cell Lysate at 30 ug Primary: Anti-Plakophilin 4 (SL12711R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 132 kD Observed band size: 132 kD

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