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Product Name SP6/KLF14 Chinese Name 转录因子SP6抗体 Alias MGC119665; Epfn; EPIPROFIN; KLF14; Krueppel-like factor 14; MGC119662; MGC119663; MGC119664; Sp6; Sp6 transcription factor; SP6_HUMAN; Transcription factor Sp6. Research Area Cell biology Neurobiology Cyclin transcriptional regulatory factor Zinc finger protein Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 40kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SP6: 201-300/376 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. Sp6, also known as EPFN, EPIPROFIN or KLF14, is a 376 amino acid protein that localizes to the nucleus and contains three C2H2-type zinc fingers. Expressed ubiquitously with higher expression in developing teeth, hair follicles and limb buds, Sp6 functions to bind GC-rich sequences and related GT and CACCC boxes, thereby promoting cellular proliferation. Human Sp6 shares 96% sequence homology with its mouse counterpart, suggesting a conserved role between species. The gene encoding Sp6 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
Function:
Promotes cell proliferation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.
SWISS:
Q3SY56
Gene ID:
80320
Database links:Entrez Gene: 80320 Human
Entrez Gene: 83395 Mouse
Omim: 608613 Human
SwissProt: Q3SY56 Human
SwissProt: Q9ESX2 Mouse
Unigene: 253603 Human
Unigene: 156282 Mouse
Unigene: 476096 Mouse
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