Product Name	PDZD3
Chinese Name	PDZ结构域PDZK3蛋白抗体
Alias	IKEPP; Intestinal and kidney enriched PDZ protein; Intestinal and kidney-enriched PDZ protein; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Na/Pi cotransporter C terminal associated protein 2; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; NHERF-4; NHERF4; NHRF4_HUMAN; PDZ domain containing 2; PDZ domain containing 3; PDZ domain containing protein 2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; PDZD 3; Pdzd3; PDZK2; Protein DLNB27; Sodium-hydrogen exchanger regulatory factor 4.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	61kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PDZD3: 101-200/571
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008] Function: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. Subcellular Location: Cell membrane. Cytoplasm. Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells. Tissue Specificity: Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin. Similarity: Contains 4 PDZ (DHR) domains. SWISS: Q86UT5 Gene ID: 607146 Database links: Entrez Gene: 79849 Human Entrez Gene: 170761 Mouse Entrez Gene: 500986 Rat Omim: 607146 Human SwissProt: Q86UT5 Human SwissProt: Q99MJ6 Mouse Unigene: 374726 Human Unigene: 29872 Mouse Unigene: 54119 Rat

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