Product Name	PDS5B
Chinese Name	雄激素诱导细胞增殖抑制蛋白抗体
Alias	AI646570; Androgen induced proliferation inhibitor; Androgen-induced prostate proliferative shutoff associated protein AS3; APRIN; AS3; AW212954; CG008; FLJ23236; KIAA0979; mKIAA0979; PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae); Pds5b; RP1 267P19.1; Sister chromatid cohesion protein PDS5 homolog B.
Research Area	Tumour  Cell biology  Cyclin  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	165kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PDS5B: 1051-1150/1447
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, May 2010] Function: Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells. Subunit: Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (Probable). Subcellular Location: Nuclear Tissue Specificity: Widely expressed. Similarity: Belongs to the PDS5 family. Contains 3 A.T hook DNA-binding domains. Contains 1 HEAT repeat. SWISS: Q9NTI5 Gene ID: 23047 Database links: Entrez Gene: 23047 Human Entrez Gene: 100710 Mouse Entrez Gene: 304218 Rat Omim: 605333 Human SwissProt: Q9NTI5 Human SwissProt: Q4VA53 Mouse SwissProt: Q6TRW4 Rat
Product Picture	Sample: Brain (Mouse) Lysate at 40 ug Primary: Anti-PDS5B (SL12605R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 165 kD Observed band size: 165 kD

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