Product Name	PDE8A
Chinese Name	磷酸二酯酶8A抗体
Alias	5''-cyclic phosphodiesterase 8A; cAMP specific cyclic nucleotide phosphodiesterase 8A; cAMP-specific cyclic nucleotide phosphodiesterase 8A; FLJ16150; High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A; High affinity cAMP-specific and IBMX-insensitive 3''; High-affinity cAMP-specific and IBMX-insensitive 3'5'-cyclic phosphodiesterase 8A; HsT19550; PDE 8A; PDE8A; PDE8A_HUMAN; Phosphodiesterase 8A; Phosphodiesterase8A; Weakly similar to 3'5' cyclic nucleotide phosphodiesterase; Weakly similar to 3'5'-cyclic-nucleotide phosphodiesterase.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	98-102kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PDE8A: 201-300/829
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Tissue Specificity: Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon. Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 1 PAS (PER-ARNT-SIM) domain. SWISS: O60658 Gene ID: 5151 Database links: Entrez Gene: 5151 Human Entrez Gene: 18584 Mouse Entrez Gene: 308776 Rat Omim: 602972 Human SwissProt: O60658 Human SwissProt: O88502 Mouse Unigene: 9333 Human Unigene: 371577 Mouse Unigene: 24771 Rat

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