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Product Name FGF3 Chinese Name 纤维母细胞生长因子3抗体 Alias FGF 3; Oncogene INT2; Fibroblast growth factor 3; HBGF 3; HBGF3; INT 2; INT 2 proto oncogene protein; INT 2 proto oncogene protein precurosr; INT2; INT2 proto oncogene protein precurosr; Murine mammary tumor virus integration site (v int 2) oncogene homolog; Murine mammary tumor virus integration site 2; Oncogene INT2; V INT2 murine mammary tumor virus integration site oncogene homolog; FGF3_MOUSE. literatures Specific References (2) | SL1255R has been referenced in 2 publications.[IF=2.507] Yamaji K et al. Maldevelopment of the submandibular gland in a mouse model of Apert syndrome. (2018) Dev Dyn. 2018 Sep 25. IHC ; Mouse.[IF=1.77] Lu et al. Changes in expression and secretion patterns of fibroblast growth factor 8 and Sonic Hedgehog signaling pathway molecules during murine neural stem/progenitor cell differentiation in vitro. (2012) Neural.Regen.Res. 7:1688-94 WB ; Mouse, Rat.Research Area Tumour Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 25kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FGF3: 66-180/245 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.
Function:
Fibroblast growth factors (FGFs) can stimulate the proliferation of mesenchymal, epithelial and neuroectodermal cells. FGF3 belongs to the heparin binding growth factors family. Members of the family include Acidic FGF (also known as aFGF or FGF 1), basic FGF (bFGF or FGF 2), FGF 3 (also known as Int2) and FGF 4 (also known as hst or Kaposi FGF). FGF 4 was first revealed to be an oncoprotein in Kaposi's sarcoma cells. Other family members include FGF 5, FGF 6, FGF 7 (keratinocyte growth factor, KGF), FGF 8 (AIGF), FGF 9 (GAF) and FGF 10. FGF3 is activated by proviral insertion of mouse mammary tumor virus (MMTV). FGF3 is responsible for most of breast malignancies.
Subunit:
Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).
Subcellular Location:
Secreted.
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the heparin-binding growth factors family.
SWISS:
P05524
Gene ID:
2248
Database links:Entrez Gene: 2248 Human
Entrez Gene: 14174 Mouse
Omim: 164950 Human
SwissProt: P11487 Human
SwissProt: P05524 Mouse
Unigene: 37092 Human
纤维母细胞生长因子3是FGF家族的成员。FGF家族参与一系列的生理功能:胚胎发育、细胞生长、器官形成、组织修复、Tumour生长、侵袭等。FGF3/FGF4在很多恶性Tumour中呈高表达,被视为原癌基因之一。Product Picture Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FGF3) Polyclonal Antibody, Unconjugated (SL1255R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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