Product Name	phospho-MYBL2 (Thr487)
Chinese Name	磷酸化转录因子MYB相关蛋白B抗体
Alias	B MyB (phospho T487); B MyB (phospho T487); MYBB_HUMAN; Myb-related protein B; BMYB; B-Myb; B MyB; Myb-like protein 2;
Product Type	Phosphorylated anti
Research Area	Cell biology  Signal transduction  Cyclin  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	79kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide derived from human MYBL2 around the phosphorylation site of Thr487: VT(p-T)PL
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in the regulation of cell survival, proliferation, and differentiation. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Function: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene. Subunit: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity. Similarity: Contains 3 HTH myb-type DNA-binding domains. SWISS: P10244 Gene ID: 4605 Database links: Entrez Gene: 4605 Human Entrez Gene: 17865 Mouse Entrez Gene: 296344 Rat Omim: 601415 Human SwissProt: P10244 Human SwissProt: P48972 Mouse Unigene: 179718 Human Unigene: 4594 Mouse Unigene: 20824 Rat

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