TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Attractin Chinese Name Attractin蛋白抗体 Alias ATRN; ATRN_HUMAN; attractin 2; Attractin; attractin-2; DPPT L; DPPT-L; KIAA0548; Mahogany homolog; mahogany protein; MGCA. Research Area Tumour Cell biology Neurobiology Cell adhesion molecule t-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 150kDa Cellular localization The cell membrane Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Attractin: 1201-1300/1429 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Mahogany (MG), originally identified as a protein involved in pigmentation, acts in conjunction with melanocortin receptors to suppress diet-induced obesity. Mahogany contains a single transmembrane domain, and it is expressed in a broad range of tissues, including the hypothalamus and pigment cells. Mutations within the mahogany gene were shown to rescue agouti-lethal-yellow mutant mice from obesity. The extracellular domain of mouse mahogany is the ortholog of the human protein attractin. Attractin (also designated DPPT-L) is a human serum glycoprotein and is a member of the CUB family of cell adhesion and guidance proteins. Attractin is expressed on activated T cells and is released from the cells 48 to 72 hours after activation.
Function:
Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system.
Subunit:
Monomer and homotrimer.
Subcellular Location:
Secreted and Cell membrane.
Tissue Specificity:
Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes.
Post-translational modifications:
Heavily glycosylated.
Similarity:
Contains 1 C-type lectin domain.
Contains 1 CUB domain.
Contains 1 EGF-like domain.
Contains 6 Kelch repeats.
Contains 2 laminin EGF-like domains.
Contains 4 PSI domains.
SWISS:
O75882
Gene ID:
8455
Database links:Entrez Gene: 8455 Human
Entrez Gene: 11990 Mouse
Omim: 603130 Human
SwissProt: O75882 Human
SwissProt: Q9WU60 Mouse
Unigene: 276252 Human
Unigene: 119936 Mouse
attractin在黑色素沉着、调节运动行为和基础代谢、中枢神经的形成及功能、协调T细胞与巨噬细胞之间的反应等方面都发挥着作用。
Scan Wechat Qrcode