Product Name	ATP6V0D2
Chinese Name	ATP6V0D2蛋白抗体
Alias	V-ATPase D2; ATP6D2; ATPase H+ transporting lysosomal 38kDa V0 subunit D; ATPase H+ transporting lysosomal 38kDa V0 subunit D isoform 2; ATPase H+ transporting lysosomal 38kDa V0 subunit D2; FLJ38708; V ATPase subunit d 2; Vacuolar ATP synthase subunit d 2; Vacuolar proton pump subunit d 2; VMA 6; VMA6; VA0D2_HUMAN.
literatures	Specific References  (7)     |     SL12548R has been referenced in 7 publications. [IF=14.919] Dai, Bingyang. et al. Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis. Nat Commun. 2022 Jan;13(1):1-17  WB ;  Mouse.   PubMed:35058428 [IF=6.656] Yuxin Li. et al. Structure-based virtual screening for discovery of Paederosidic Acid from Paederia Scandens as novel P2Y14R antagonist. PHYTOMEDICINE. 2023 May;:154851  WB ;  Mouse.   PubMed:37149963 [IF=6.15] Fang, Chao. et al. Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion. Acta Pharmacol Sin. 2021 Aug;:1-12  WB ;  Mouse.   PubMed:34381182 [IF=5.051] Hasegawa Tomoka. et al. Evocalcet rescues secondary hyperparathyroidism-driven cortical porosity in chronic kidney disease male rats. ENDOCRINOLOGY. 2023 Jan;:  IHC ;  Rat.   PubMed:36718587 [IF=4.966] Hirohito Hirata. et al. PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking. Faseb J. 2021 Feb;35(2):e21281  IF ;  Mouse.   PubMed:33484199 [IF=4.141] Junfeng He. et al. Distribution and Expression of Pulmonary Ionocyte-Related Factors CFTR, ATP6V0D2, and ATP6V1C2 in the Lungs of Yaks at Different Ages. GENES-BASEL. 2023 Mar;14(3):597  IHC ;  Bovine.   PubMed:10.3390/genes14030597 [IF=3.448] Ma Q et al. Non‐coenzyme role of vitamin B1 in RANKL‐induced osteoclastogenesis and ovariectomy induced osteoporosis. J Cell Biochem. 2020 Feb 26.  WB ;  mouse.   PubMed:32100911
Research Area	Tumour  Cell biology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ATP6V0D2/V-ATPase D2: 251-350/350
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. V-ATPase D2 is a 350 amino acid protein that is expressed in kidney, lung and osteoclast. V-ATPase D2 has been implicated as a regulator of urine acidification, osteoclast fusion and bone formation. Furthermore, V-ATPase D2 has been identified as a dendritic cell marker. Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Subunit: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Subcellular Location: Apical plasma membrane. Tissue Specificity: Kidney, osteoclast and lung. Similarity: Belongs to the V-ATPase V0D/AC39 subunit family. SWISS: Q8N8Y2 Gene ID: 245972 Database links: Entrez Gene: 245972 Human Entrez Gene: 242341 Mouse Entrez Gene: 297932 Rat SwissProt: Q8N8Y2 Human SwissProt: Q80SY3 Mouse SwissProt: Q5FVL0 Rat Unigene: 436360 Human
Product Picture	Sample: Lane 1: Human HeLa cell lysates Lane 2: Human A549 cell lysates Primary: Anti-ATP6V0D2 (SL12548R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 40 kDa

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