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Product Name ARSI Chinese Name 芳香基硫酸酯酶家族蛋白1抗体 Alias Arylsulfatase family, member I; arylsulfatase I; ASI; EC 3.1.6; FLJ16069; ARSI_HUMAN. Research Area Cell biology Signal transduction Growth factors and hormones The new supersedes the old Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 61kDa Cellular localization cytoplasmic Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ARSI: 101-200/569 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Sulfatases (EC 3.1.5.6), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008].
Function:
Sulfatases such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules
Subcellular Location:
Endoplasmic reticulum and Secreted
Tissue Specificity:
Expressed in placenta, in embryonic stem cells, fetal eyes and lens.
Post-translational modifications:
The oxidation of Cys-93 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying factor 1, seems critical for catalytic activity.
Similarity:
Belongs to the sulfatase family.
SWISS:
Q5FYB1
Gene ID:
340075
Database links:Entrez Gene: 340075 Human
Omim: 610009 Human
SwissProt: Q5FYB1 Human
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