Product Name	APRG1
Chinese Name	三号染色体开放阅读框抗体
Alias	AP20 region protein 1; APRG1; APRG1_HUMAN; C3orf35; chromosome 3 open reading frame 35.
Research Area	Tumour  Cell biology  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	19kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human APRG1/C3orf35: 41-140/170
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	APRG1 is a 170 amino acid single-pass membrane protein that exists as 3 alternatively spliced isoforms. APRG1 isoform 1 is highly expressed in placenta and pancreas, while isoform 2 is mainly expressed in kidney. The gene encoding APRG1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3. Subcellular Location: Membrane; Single-pass membrane protein (Potential). Tissue Specificity: Isoform 1 is expressed at high levels in the pancreas and placenta. Isoform 2 is expressed at high levels in the kidney. SWISS: Q8IVJ8 Gene ID: 339883 Database links: Entrez Gene: 339883 Human Omim: 611429 Human SwissProt: Q8IVJ8 Human Unigene: 475945 Human

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