TEL: +86 571 56623320 EMAIL: [email protected]
Product Name APC2 Chinese Name 腺瘤性结肠息肉病蛋白2抗体 Alias Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APCL; APC2_HUMAN. Research Area Tumour immunology Cell adhesion molecule Cytoskeleton Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 244kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human APCL/APC2: 1-100/2303 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner’s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin.
Function:
APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor.
Subunit:
Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2.
Subcellular Location:
Cell Membrane, Cytoplasmic and Golgi Apparatus
Tissue Specificity:
Widely expressed (at protein level). Specifically expressed in the CNS.
Similarity:
Belongs to the adenomatous polyposis coli (APC) family.
Contains 6 ARM repeats.
SWISS:
Q9UJX6
Gene ID:
29882
Database links:Entrez Gene: 29882 Human
Entrez Gene: 99152 Mouse
Omim: 606946 Human
SwissProt: Q9UJX6 Human
SwissProt: Q8BZQ7 Mouse
Unigene: 434898 Human
Unigene: 533262 Human
Unigene: 291624 Mouse
Scan Wechat Qrcode