Product Name	TMEM16C
Chinese Name	Transmembrane protein16C抗体
Alias	Anoctamin 3; ANO3; C11orf25; GENX 3947; TMEM16C; Transmembrane protein 16C (eight membrane spanning domains); Transmembrane protein 16C; ANO3_HUMAN; DYT23; DYT24; GENX-3947.
Research Area	Tumour  Cell biology  Signal transduction  The new supersedes the old  Transmembrane protein  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	115kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TMEM16C/Anoctamin 3: 801-900/981 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TMEM16C is a 981 amino acid multi-pass membrane protein that is encoded by a gene which maps to chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11. Function: Anoctamin 3 belongs to the anoctamin family. Anoctamin 3 may act as a calcium activated chloride channel. Subcellular Location: Membrane; Multi pass membrane protein. Similarity: Belongs to the anoctamin family. SWISS: Q9BYT9 Gene ID: 63982 Database links: Entrez Gene: 63982 Human Entrez Gene: 228432 Mouse Entrez Gene: 100519534 Pig Entrez Gene: 311287 Rat Omim: 610110 Human SwissProt: Q9BYT9 Human SwissProt: A2AHL1 Mouse SwissProt: F1SFZ6 Pig

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