Product Name	ANKK1
Chinese Name	锚定蛋白重复结构域蛋白激酶ANKK1抗体
Alias	Ankyrin repeat and kinase domain containing 1; Ankyrin repeat and protein kinase domain containing protein 1; EC 2.7.11.1; PKK2; Protein kinase PKK2; SGK288; Sugen kinase 288; X kinase; ANKK1_HUMAN.
Research Area	Signal transduction  Apoptosis  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Chicken, Dog, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	85kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ANKK1: 101-200/765
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. ANKK1 (ankyrin repeat and kinase domain containing 1), also known as PKK2 or SGK288, is a 765 amino acid protein that belongs to the Ser/Thr protein kinase family and contains 12 ANK repeats and one protein kinase domain. Highly expressed in brain tissue and present in lower amounts in placenta and spinal cord, ANKK1 functions to catalyze the ATP-dependent phosphorylation of target proteins and is thought to play a role in alcohol and nicotine dependence. The gene encoding ANKK1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Function: ANKK1 belongs to the TKL Ser/Thr protein kinase superfamily, contains twelve ANK repeats and one protein kinase domain. The protein is weakly expressed in testis, placenta, and spinal cord. Tissue Specificity: Highly expressed in brain and weakly expressed in placenta and spinal cord. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 12 ANK repeats. Contains 1 protein kinase domain. SWISS: Q8NFD2 Gene ID: 255239 Database links: Entrez Gene: 785303 Cow Entrez Gene: 489403 Dog Entrez Gene: 100054819 Horse Entrez Gene: 255239 Human Omim: 608774 Human SwissProt: Q8NFD2 Human Unigene: 448473 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat lung); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Ankyrin repeat and kinase domain containing 1; ANKK1) Polyclonal Antibody, Unconjugated (SL12475R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Ankyrin repeat and kinase domain containing 1; ANKK1) Polyclonal Antibody, Unconjugated (SL12475R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining.

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