Product Name	LTBP1
Chinese Name	转化生长因子β1Binding protein1抗体
Alias	9430031G15Rik; 9830146M04; Latent transforming growth factor beta binding protein 1; Latent-transforming growth factor beta-binding protein 1; Latent-transforming growth factor beta-binding protein, isoform 1L; Latent-transforming growth factor beta-binding protein, isoform 1S; LBT1S; LTBP-1; Ltbp1; LTBP1_HUMAN; MGC163161; TGF-beta1-BP-1; Tgfb; Transforming growth factor beta-1-binding protein 1; Transforming growth factor beta-1-masking protein large subunit.
literatures	Specific References  (1)     |     SL12413R has been referenced in 1 publications. [IF=0] William J. Burlingham. et al. Extracellular Vesicle–associated GARP/TGFβ:LAP Mediates “Infectious” Allo-tolerance. TRANSPLANT DIRECT. 2023 Jun; 9(6): e1475  ELISA ;  Mouse.   PubMed:37250483
Research Area	Tumour  Cell biology  Signal transduction  Stem cells  Growth factors and hormones  transcriptional regulatory factor  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Rabbit, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	184kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LTBP1: 221-320/1721
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Latent transforming growth factor-beta 1 binding protein 1 (LTBP-1), a heavy glycoprotein, is part of the platelet-derived TGF-beta 1 complex. LTBP-1 serves as an anchor for latent TGF-beta in the extracellular matrix and is a component of microfibrillar structures. Cleavage of LTBP results in LTBP-1, which may sequester latent TGF-beta in the extracellular matrix and regulate its activation. LTBP-1 mRNA is enriched in ovarian carcinoma tissues and highly expressed in serous and mucinous adenocarcinomas. Function: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM). Subunit: The large latent complex of TGFB1 from platelets is composed of the TGFB1 molecule non-covalently associated with a disulfide-bonded complex of a dimer of the N-terminal propeptide of the TGFB1 precursor and LTBP1. LTBP1 does not bind directly to active TGFB1. Binds to FBN1 and FBN2. Interacts with ADAMTSL2. Subcellular Location: Secreted. Tissue Specificity: Isoform Long is found in fibroblasts. Post-translational modifications: Contains hydroxylated asparagine residues. Isoform Short N-terminus is blocked. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. Similarity: Belongs to the LTBP family. Contains 18 EGF-like domains. Contains 4 TB (TGF-beta binding) domains. SWISS: Q14766 Gene ID: 4052 Database links: Entrez Gene: 4052 Human Entrez Gene: 268977 Mouse Entrez Gene: 59107 Rat Omim: 150390 Human SwissProt: Q14766 Human SwissProt: Q8CG19 Mouse SwissProt: Q00918 Rat Unigene: 619315 Human Unigene: 269747 Mouse Unigene: 40942 Rat

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