Product Name	Stanniocalcin 2
Chinese Name	斯钙素2抗体
Alias	Stanniocalcin related protein; Stanniocalcin-2; Stanniocalcin-related protein; Stanniocalcin2; STC 2; STC related protein; STC-2; STC-related protein; STC2; STC2_HUMAN; STCRP.
Research Area	Cell biology  Developmental biology  Signal transduction  Stem cells  glycoprotein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	31kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Stanniocalcin 2: 81-180/302
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2) are mammalian peptide hormones that were previously considered to be present only in bony fish, where they are involved in calcium homeostasis. STC1 plays a role in calcium and phosphate homoeostasis and is phosphorylated in vitro by protein kinase C, and STC2 is phosphorylated in vitro by casein kinase II (CK2). A human fibrosarcoma cell line, HT1080, expresses both STC1 and STC2 as secreted phosphoproteins in vivo, with STC2 being phosphorylated by an ecto-CK2-like enzyme. STC1 and STC2 have opposite effects on calcium and phosphate homeostasis, namely anti-hypercalcemic and anti-hypocalcemic actions, respectively. STC1 and STC2 are detected in human adrenal tumors, such as pheochromocytoma, differentiated neuroblastoma aldosterone-producing adenoma, and in cultured adrenal tumor cells (rat pheochromocytoma PC-12 cells and human neuroblastoma NB-1 cells). Function: Has an anti-hypocalcemic action on calcium and phosphate homeostasis. Subcellular Location: Secreted. Tissue Specificity: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes. Similarity: Belongs to the stanniocalcin family. SWISS: O76061 Gene ID: 8614 Database links: Entrez Gene: 540573 Cow Entrez Gene: 8614 Human Entrez Gene: 20856 Mouse Entrez Gene: 100126236 Pig Entrez Gene: 63878 Rat Entrez Gene: 548758 Xenopus tropicalis Omim: 603665 Human SwissProt: O76061 Human SwissProt: O88452 Mouse SwissProt: Q9R0K8 Rat Unigene: 233160 Human Unigene: 32506 Mouse Unigene: 44823 Rat

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