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Product Name Involucrin Chinese Name 囊包蛋白/内披蛋白抗体 Alias INVO_HUMAN; involucrin; ivl. Research Area Cell biology Signal transduction Cyclin Cytoskeleton Extracellular matrix Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 64kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Involucrin: 65-180/585 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].
Function:
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Subunit:
Directly or indirectly cross-linked to cornifelin (CNFN).
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Keratinocytes of epidermis and other stratified squamous epithelia.
Post-translational modifications:
Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.
Similarity:
Belongs to the involucrin family.
SWISS:
P07476
Gene ID:
3713
Database links:Entrez Gene: 3713 Human
Entrez Gene: 16447 Mouse
Omim: 147360 Human
SwissProt: P07476 Human
SwissProt: P48997 Mouse
Unigene: 516439 Human
Unigene: 207365 Mouse
Unigene: 142591 Rat
套膜蛋白又称内披蛋白或囊包蛋白,与毛透明蛋白共同构成角质细胞包膜支架的蛋白质。在角质Cell differentiation时,首先出现在表皮棘层的上层细胞中的标志性蛋白质,该蛋白在角质细胞和其他复层扁平上皮合成的蛋白。最初存在于细胞质中,然后通过转谷氨酰胺酶的作用,转变为交联的膜蛋白。
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