Product Name	MIXL1
Chinese Name	同源结构蛋白1抗体
Alias	hMix; Homeobox protein MIXL1; Homeodomain protein 1; Homeodomain protein MIX; MILD1; MIX; Mix.1; Mix.1 homeobox-like protein; Mix1 homeobox-like 1; MIX1 homeobox-like protein 1; Mixl1; MIXL1_HUMAN.
Research Area	Cell biology  Developmental biology  Signal transduction  Stem cells  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human MIXL1: 101-200/232
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and in the control of gene expression. MIXL1 (Mix1 homeobox-like 1), also known as MIXL, is a 232 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Expressed in lymph tissues, MIXL1 functions as a transcription factor that plays an essential role in axial mesendoderm morphogenesis and endoderm formation and is also required for cellular differentiation during blood development. Additionally, MIXL1 is involved in maturation of heart and gut tissue during embryogenesis and may also act as a negative regulator of brachyury expression. Overexpression of MIXL1 is associated with non-Hodgkin and Hodgkin lymphomas, suggesting a role in carcinogenesis. Function: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression. Subcellular Location: Nucleus. Tissue Specificity: Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B-and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level). Post-translational modifications: Phosphorylated at multiple sites. Similarity: Belongs to the paired homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: Q9H2W2 Gene ID: 83881 Database links: Entrez Gene: 83881 Human Entrez Gene: 27217 Mouse Omim: 609852 Human SwissProt: Q9H2W2 Human SwissProt: Q9WUI0 Mouse Unigene: 282079 Human Unigene: 103647 Mouse
Product Picture	Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti- MIXL1 (SL12350R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25 kD Observed band size: 23 kD

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