Product Name	SCUBE3
Chinese Name	新型分泌细胞表面蛋白/成骨细胞相关蛋白SCUBE3抗体
Alias	CEGF3; CUB and EGF containing protein 3; CUB and EGF-like domain-containing protein 3; CUB domain and EGF like repeat containing 3; DKFZp686B09105; DKFZp686B1223; DKFZp686D20108; FLJ34743; OTTHUMP00000016250; SCUB3_HUMAN; SCUBE 3; SCUBE3; Signal peptide; Signal peptide CUB and EGF like domain containing protein 3; Signal peptide CUB domain EGF like 3.
Research Area	Developmental biology  Signal transduction  Stem cells  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	107kDa
Cellular localization	The cell membrane Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human SCUBE3: 451-550/993
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SCUBE3 is a novel secreted 993 amino acid cell-surface osteoblast protein that plays an important role in bone cell biology. While highly expressed in osteoblasts, SCUBE3 expression is unobservable or very low in non-bone tissues. SCUBE3 forms homo-oligomers and hetero-oligomers with SCUBE1, and may undergo C-terminal proteolytic cleavage or become N-glycosylated following translation. Two SCUBE3 isoforms exist as a result of alternative splicing events. SCUBE3 contains one CUB domain and nine EGF-like domains, and is encoded by a gene which maps to human chromosome 6p21.31, a region associated with a rare form of metabolic bone disease known as Paget's disease. Chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome. Function: Binds to TGFBR2 and activates TGFB signaling. In lungcancer cells, could serve as an endogenous autocrine and paracrineligand of TGFBR2, which could regulate TGFBR2 signaling and hencemodulate epithelial-mesenchymal transition and cancer progression. Subunit: Forms homooligomers and heterooligomers with SCUBE1.Interacts with TGFBR2 through the CUB domain; this interaction doesnot affect TGFB1-binding to TGFBR2. Subcellular Location: Secreted. Cell surface. Tissue Specificity: Highly expressed in osteoblasts. Expression is low or absent in non-bone tissues. Post-translational modifications: N-glycosylated. May undergo proteolytic cleavage in the C-terminal region. Similarity: Contains 1 CUB domain. Contains 9 EGF-like domains. SWISS: Q8IX30 Gene ID: 222663 Database links: Entrez Gene: 222663 Human Entrez Gene: 268935 Mouse Omim: 614708 Human SwissProt: Q8IX30 Human SwissProt: Q66PY1 Mouse Unigene: 12923 Human Unigene: 258491 Mouse

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