Product Name	PBX3
Chinese Name	Blymphocyte白血病前体蛋白转录因子3抗体
Alias	Homeobox protein PBX3; MGC134053; OTTHUMP00000064213; Pbx 3; Pbx3; PBX3_HUMAN; Pre B cell leukemia homeobox 3; Pre B cell leukemia transcription factor 3; Pre-B-cell leukemia transcription factor 3; RP11 336P12.1.
literatures	Specific References  (1)     |     SL12295R has been referenced in 1 publications. [IF=1.39] Ma et al. High level of homeobox A9 and PBX homeobox 3 expression in gastric cancer correlates with poor prognosis. (2017) Oncol.Lett. 14:5883-5889  IHC-P ;  Human.   PubMed:29113222
Research Area	transcriptional regulatory factor  lymphocyte  b-lymphocyte  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	47kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human PBX3: 65-130/434
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Pbx 1, 2, 3 and 4 are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. Human pre-B cell acute leukemias are frequently associated with a t(1;19)(q23;p13.3) chromosomal rearrangement, which creates a chimeric gene encoding a fusion between the E2A and Pbx 1 gene products. Pbx 2 and Pbx 3 share 92% and 94% respective identities with Pbx 1 over a 266 amino acid region flanking their homeobox domains, while all three proteins are quite divergent at their amino- and carboxy-termini. Two forms of Pbx 1 and Pbx 3 each differ primarily in their carboxy-termini and result from alternative mRNA splicing. Unlike other homeotic selector genes which are expressed transiently during development and differentiation, Pbx gene transcripts are ubiquitously expressed in both fetal and adult tissues and cell lines. Additionally, Pbx 2 and Pbx 3 transcripts are detected in lymphoid cells, which do not express Pbx 1. Pbx 4 expression is confined to the testis, especially to spermatocytes in the pachytene stage of the first meiotic prophase. Function: Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed Similarity: Belongs to the TALE/PBX homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: P40426 Gene ID: 5090 Database links: Entrez Gene: 417093 Chicken Entrez Gene: 539222 Cow Entrez Gene: 5090 Human Entrez Gene: 18516 Mouse Entrez Gene: 311876 Rat Omim: 176312 Human SwissProt: P40426 Human SwissProt: O35317 Mouse

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