Product Name	DDX3Y
Chinese Name	精子发育相关蛋白DDX3Y抗体
Alias	DBY; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 Y linked; DEAD box protein 3 Y chromosomal; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide Y chromosome; DDX3Y_HUMAN.
Research Area	Cell biology  Developmental biology  Stem cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	73kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human DDX3Y: 401-500/660
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	DDX3X is encoded by a gene found on the X chromosome while DDX3Y is encoded by a gene on the Y chromosome. DDX3Y is exclusively expressed in testis and is required for normal spermatogenesis. DDX3X is ubiquitously expressed and predominantly localizes to the nuclear speckles, participating in RNA splicing, transcription, translation initiation, mRNA transport and cell cycle regulation. DDX3X also partakes in HIV-1 replication and hepatitis C viral infections. Function: DEAD box proteins are putative RNA helicases, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as ribosome and spliceosome assembly, translation initiation and nuclear and mitochondrial splicing. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome. Mutations in DDX3Y cause male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that it plays a key role in the spermatogenic process. Alternatively spliced variants, encoding the same protein, have been identified. Subunit: May interact with TDRD3. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Testis-specific. Expressed predominantly in spermatogonia. DISEASE: Note=DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia. Similarity: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. SWISS: O15523 Gene ID: 8653 Database links: Entrez Gene: 8653 Human Entrez Gene: 26900 Mouse Entrez Gene: 100312982 Rat Omim: 400010 Human SwissProt: O15523 Human SwissProt: Q62095 Mouse

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