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Product Name SOHLH2 Chinese Name 精子卵子结合生成碱性螺旋蛋白2抗体 Alias FLJ20449; FLJ57222; Solh2; Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2; TEB1; SOLH2_HUMAN. literatures Specific References (1) | SL12279R has been referenced in 1 publications.[IF=3.45] Ding, Jin, et al. "Protection of Murine Spermatogenesis Against Ionizing Radiation-Induced Testicular Injury by a Green Tea Polyphenol." Biology of Reproduction (2014): biolreprod-114. Mouse.Research Area Cell biology Developmental biology Stem cells transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 47kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from Human SOHLH2: 221-320/425 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail SOHLH2 is a 425 amino acid nuclear protein that contains one basic helix-loop-helix (bHLH) domain through which it may function as a transcription factor during oogenesis and spermatogenesis. SOHLH2 exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 13q13.3. Chromosome 13 houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
Function:
Sohlh2, spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2, is a basic loop helix transcription factor. Sohlh2 is normally expressed in pre-meiotic germ cells and testis and involved in spermatogenesis and oogenesis. Male Sohlh2 deficient mice are infertile due to a block in spermatogenesis.
Subcellular Location:
Nuclear
Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.
SWISS:
Q9NX45
Gene ID:
100526761
Database links:Entrez Gene: 100526761 Human
Entrez Gene: 54937 Human
SwissProt: Q9NX45 Human
Unigene: 124519 Human
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