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Rabbit Anti-SOHLH2 antibody
Rabbit Anti-SOHLH2 antibody
FLJ20449; FLJ57222; Solh2; Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2; TEB1; SOLH2_HUMAN.
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  • NO.:SL12279R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,)
    Applications:ELISA
    concentration:1mg/ml
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Details

Product Name SOHLH2
Chinese Name 精子卵子结合生成碱性螺旋蛋白2抗体
Alias FLJ20449; FLJ57222; Solh2; Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2; TEB1; SOLH2_HUMAN.  
literatures
Specific References  (1)     |     SL12279R has been referenced in 1 publications.
[IF=3.45] Ding, Jin, et al. "Protection of Murine Spermatogenesis Against Ionizing Radiation-Induced Testicular Injury by a Green Tea Polyphenol." Biology of Reproduction (2014): biolreprod-114.  Mouse.  
Research Area Cell biology  Developmental biology  Stem cells  transcriptional regulatory factor  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, )
Applications ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 47kDa
Cellular localization The nucleus 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from Human SOHLH2: 221-320/425 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail SOHLH2 is a 425 amino acid nuclear protein that contains one basic helix-loop-helix (bHLH) domain through which it may function as a transcription factor during oogenesis and spermatogenesis. SOHLH2 exists as two alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 13q13.3. Chromosome 13 houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.

Function:
Sohlh2, spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2, is a basic loop helix transcription factor. Sohlh2 is normally expressed in pre-meiotic germ cells and testis and involved in spermatogenesis and oogenesis. Male Sohlh2 deficient mice are infertile due to a block in spermatogenesis.

Subcellular Location:
Nuclear

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.

SWISS:
Q9NX45

Gene ID:
100526761

Database links:

Entrez Gene: 100526761 Human

Entrez Gene: 54937 Human

SwissProt: Q9NX45 Human

Unigene: 124519 Human



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