Product Name	Nodal
Chinese Name	胚胎发育相关蛋白Nodal抗体
Alias	MGC138230; Nodal; nodal homolog (mouse); Nodal homolog; NODAL_HUMAN.
literatures	Specific References  (1)     |     SL12243R has been referenced in 1 publications. [IF=3.231] Yan Qi. et al. The Photoperiod Regulates Granulosa Cell Apoptosis through the FSH-Nodal/ALK7 Signaling Pathway in Phodopus sungorus. ANIMALS. 2022 Jan;12(24):3570  IF ;  Hamster.   PubMed:36552491
Research Area	Developmental biology  Neurobiology  Stem cells  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	13kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human Nodal: 288-347/347
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The transforming growth factor Beta (TGF Beta) superfamily is composed of numerous growth and differentiation factors, including TGF Beta 1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin Alpha, Beta-A, Beta-B and Beta-C, Lefty and Nodal. Members of the TGF Beta superfamily are involved in embryonic development and adult tissue homeostasis. Ectodermal cells through the primitive streak delaminate and differentiate into mesoderm during gastrulation. Nodal expression is detectable in the primitive streak at the time of mesoderm formation, indicating a potential role for Nodal in mesoderm formation. Nodal has also been shown to be involved in the direction of heart looping and embryonic turning. Function: Essential for mesoderm formation and axial patterning during embryonic development. Subunit: Homodimer; disulfide-linked (By similarity). Subcellular Location: Secreted. DISEASE: Defects in NODAL are the cause of visceral heterotaxy autosomal type 5 (HTX5) [MIM:270100]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy autosomal type 5 include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncuscommunis, and dextrocardia. Similarity: Belongs to the TGF-beta family. SWISS: Q96S42 Gene ID: 4838 Database links: Entrez Gene: 4838 Human Omim: 601265 Human SwissProt: Q96S42 Human Unigene: 370414 Human

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