Product Name	ZNF350
Chinese Name	Zinc finger protein350/乳腺癌易感基因1Binding protein抗体
Alias	KRAB zinc finger protein ZFQR; ZBRK1; ZFQR; Zinc finger and BRCA1 interacting protein with a KRAB domain 1; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; Zinc finger protein 350; Zinc finger protein ZBRK1; ZN350_HUMAN; ZNF350.
Research Area	Tumour  transcriptional regulatory factor  Zinc finger protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	60kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human ZNF350/ZBRK1: 101-220/532
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The transcpritional repressor ZBRK1, also designated zinc finger and BRCA1-interacting protein with a KRAB domain 1 or zinc finger protein 350, belongs to the Krüppel C2H2-type zinc-finger protein family of proteins. ZBRK1 localizes mainly to the nucleus and may be associated with the nuclear matrix. It is a widely expressed protein that binds to BRCA1. ZBRK1 plays an important role in transcriptional regulation. Likely targets of gene regulation are DNA damage response genes, which effect the survival and growth control of cells. ZBRK1 contains an N-terminal KRAB domain, a C-terminal BRCA1-binding region and eight central zinc-fingers. Function: Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3. Subunit: Interacts with BRCA1. Interacts with RNF11. Subcellular Location: Nucleus matrix. Associated with the nuclear matrix. Tissue Specificity: Widely expressed. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 8 C2H2-type zinc fingers. Contains 1 KRAB domain. SWISS: Q9GZX5 Gene ID: 59348 Database links: Entrez Gene: 59348 Human Entrez Gene: 234358 Mouse Entrez Gene: 100158232 Rat Omim: 605422 Human SwissProt: Q9GZX5 Human Unigene: 407694 Human

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