Product Name	ZNF281
Chinese Name	Zinc finger protein281抗体
Alias	Zfp281; GC box binding zinc finger protein 1; GC-box-binding zinc finger protein 1; GZP1; Transcription factor ZBP-99; ZBP 99; ZBP99; zfp281; Zinc finger DNA binding protein 99; Zinc finger DNA-binding protein 99; Zinc Finger Protein 281; ZN281_HUMAN; ZNF281; ZNP 99; ZNP 99 transcription factor; ZNP99.
Research Area	Cell biology  Developmental biology  Signal transduction  Stem cells  transcriptional regulatory factor  Zinc finger protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	97kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human ZNF281: 802-895/895
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF281, also known as GC-box-binding zinc finger protein 1, ZBP-99 or ZNP-99 (zinc finger DNA-binding protein 99), is a zinc finger protein that belongs to the Krüppel C2H2-type zinc finger protein family. It is expressed ubiquitously at low levels with predominant expression in kidney, liver, lymphocytes and placenta. ZNF281 localizes to the nucleus and contains four C2H2-type zinc fingers. ZNF281 plays a role in repressing the transcription of a variety of genes including Gastrin and ODC (ornithine decarboxylase). In particular, ZNF281 functions by binding to the G-rich box in the enhancer region of the gene. Upon DNA damage, ZNF281 may become phosphorylated by Atm or ATR. Function: Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin and ornithine decarboxylase. Binds to the G-rich box in the enhancer region of these genes. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 4 C2H2-type zinc fingers. SWISS: Q9Y2X9 Gene ID: 23528 Database links: Entrez Gene: 23528 Human Entrez Gene: 226442 Mouse Entrez Gene: 305083 Rat SwissProt: Q9Y2X9 Human Unigene: 59757 Human Unigene: 62521 Mouse Unigene: 204958 Rat
Product Picture	Sample: 293T(Human) Cell Lysate at 30 ug Primary: Anti- ZNF281 (SL12208R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 97 kD Observed band size: 100 kD

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