Product Name	KCNT2
Chinese Name	钙激活钾Channel proteinKCNT2抗体
Alias	KCa4.2; Potassium channel, subfamily T, member 2; Sequence like an intermediate conductance potassium channel subunit; SLICK; SLO2.1; Sodium and chloride activated ATP sensitive potassium channel; Sodium and chloride activated ATP sensitive potassium channel Slo2.1; KCNT2_HUMAN.
literatures	Specific References  (1)     |     SL12177R has been referenced in 1 publications. [IF=12.121] Benyu Liu. et al. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. Nat Commun. 2020 Aug;11(1):1-14  other ;  Mouse.   PubMed:32796851
Research Area	Neurobiology  Channel protein  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	130kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human KCNT2: 51-150/1135 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Voltage-gated K+ channels in the plasma membrane are important regulators of electrical signaling, controlling the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. KCNT2 is a 1,135 amino acid multi-pass transmembrane protein belonging to the potassium channel family (calcium-activated subfamily) of proteins. KCNT2 produces rapidly activating outward rectifier potassium currents in reponse to high intracellular sodium and chloride levels. Its channel activity is inhibited by ATP, inhalation anesthetics, such as isoflourane, and upon stimulation of G-protein coupled receptors, such as mAChR M1 and GluR-1. There are four isoforms of KCNT2 that are produced as a result of alternative splicing events. Function: KCNT2 belongs to the potassium channel family, calcium-activated subfamily and contains one RCK N-terminal domain. KCNT2 is an outward rectifying potassium channel and produces rapidly activating outward rectifier K(+) currents. It is activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane. KCNT2 is inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. There are four named isoforms. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity. Similarity: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily. Contains 1 RCK N-terminal domain. SWISS: Q6UVM3 Gene ID: 343450 Database links: Entrez Gene: 343450 Human Entrez Gene: 240776 Mouse Entrez Gene: 304827 Rat Omim: 610044 Human SwissProt: Q6UVM3 Human SwissProt: Q6UVM4 Rat

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