Product Name	KCNG3
Chinese Name	电压门控性钾Channel protein亚基KV6.3抗体
Alias	KCNG 3; Kcng3; KCNG3_HUMAN; KV10.1; Kv10.1a; Kv10.1b; KV6.3; OTTHUMP00000201478; OTTHUMP00000201479; Potassium voltage gated channel subfamily G member 3; Potassium voltage-gated channel subfamily G member 3; Voltage gated potassium channel 6.3; Voltage gated potassium channel Kv10.1; Voltage gated potassium channel subunit Kv10.1; Voltage gated potassium channel subunit Kv6.3; Voltage gated potassium channel subunit Kv6.4; Voltage-gated potassium channel subunit Kv10.1; Voltage-gated potassium channel subunit Kv6.3.
Research Area	Cell biology  Neurobiology  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IF=1:100-500  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	50kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human KCNG3: 251-350/436 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]. Function: Potassium channel subunit. Modulates channel activity. Subunit: Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers. Subcellular Location: Cell membrane. Membrane. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1. Tissue Specificity: Detected in many parts of the brain with the exception of the cerebellum, in testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland and spinal cord. Similarity: Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. SWISS: Q8TAE7 Gene ID: 170850 Database links: Entrez Gene: 170850 Human Entrez Gene: 225030 Mouse Entrez Gene: 171011 Rat Omim: 606767 Human SwissProt: Q8TAE7 Human SwissProt: P59053 Mouse SwissProt: Q8R523 Rat Unigene: 352633 Human Unigene: 223506 Mouse Unigene: 82689 Rat
Product Picture	Sample: Lane 1: Human Jurkat cell Lysates Lane 2: Human SH-SY5Y cell Lysates Primary: Anti-KCNG3 (SL12175R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50kDa Observed band size: 110kDa Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KCNG3) Polyclonal Antibody, Unconjugated (SL12175R) at 1:200 overnight at 4°C, followed by a conjugated Goat Anti-Rabbit IgG antibody (SL0295G-AF488) for 90 minutes, and DAPI for nuclei staining. Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (KCNG3) Polyclonal Antibody, Unconjugated (SL12175R) at 1:200 overnight at 4°C, followed by a conjugated Goat Anti-Rabbit IgG antibody (SL0295G-AF488) for 90 minutes, and DAPI for nuclei staining.

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