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Product Name TXLNB Chinese Name β-taxilin蛋白抗体 Alias Beta-taxilin; C6orf198; dJ522B19.2; DKFZp451A175; hMDP77; LST001; MDP77; Muscle-derived protein 77; RP3-522B19.2; Txlnb; TXLNB_HUMAN. Research Area Neurobiology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 76kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TXLNB: 331-430/684 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Beta-taxilin promotes nerve regeneration and may be involved in intracellular vesicle transport. Expressed predominantly in cardiac and skeletal muscle, beta-taxilin binds to the coiled coil region of the syntaxin family members STX1A, STX3A, and STX4A. Beta- and gamma-taxilins, bind to the alpha subunit of the nascent polypeptide-associated complex (NAC) and affect its nuclear distribution, suggesting that the taxilin family is involved not only in the translational process through its interaction with NAC but also in the transcriptional process through its interaction with alphaNAC alone.
Function:
Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.
Subunit:
Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preference for STX1A.
Tissue Specificity:
Expressed in skeletal muscle.
Similarity:
Belongs to the taxilin family.
SWISS:
Q8N3L3
Gene ID:
167838
Database links:Entrez Gene: 167838 Human
Entrez Gene: 378431 Mouse
Omim: 611438 Human
SwissProt: Q8N3L3 Human
SwissProt: Q8VBT1 Mouse
Unigene: 535820 Human
Unigene: 283493 Mouse
Unigene: 165855 Rat
Product Picture Sample: Muscle (Mouse) Lysate at 40 ug
Primary: Anti-TXLNB (SL12153R) at 1/300 dilution
Secondary: HRP conjugated Goat-Anti-rabbit IgG (SL0295G-HRP) at 1/5000 dilution
Predicted band size: 76 kD
Observed band size: 76 kD
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TXLNB) Polyclonal Antibody, Unconjugated (SL12153R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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