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Product Name DLGAP2 Chinese Name PSD95Binding protein2抗体 Alias DLGAP2; SAPAP2; DAP-2; DAP2; Discs large (Drosophila) homolog associated protein 2; Discs large homolog associated protein 2; Disks large-associated protein 2; Dlgap2; DLGP2_HUMAN; PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2; SAPAP2; hide. Research Area Neurobiology The cell membrane受体 Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 118kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SAPAP2/DLGAP2: 251-360/1054 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail A guanylate kinase is a phosphotransferase that produces ADP and GDP from the substrates ATP and GMP. SAPAP2, also known as DAP-2 (Disks large-associated protein 2) and PSD-95/SAP90-binding protein 2, is a 1054 amino acid protein that localizes to the postsynaptic membrane of neuronal cells of the brain and kidney. SAPAP2 likely acts as a signaling molecule which interacts with the human genes DLG1 and DLG4/PSD-95. The gene encoding SAPAP2, DLGAP2, maps to human chromosome 8. Consisting of nearly 146 million base pairs, chromosome 8 encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that maps to chromosome 8.
Function:
May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Subunit:
Interacts with DLG1 and DLG4/PSD-95.
Subcellular Location:
Cell membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Postsynaptic density of neuronal cells.
Tissue Specificity:
Expressed in brain and kidney.
Similarity:
Belongs to the SAPAP family.
SWISS:
Q9P1A6
Gene ID:
9228
Database links:Entrez Gene: 9228 Human
Entrez Gene: 244310 Mouse
Omim: 605438 Human
SwissProt: Q9P1A6 Human
SwissProt: Q8BJ42 Mouse
Unigene: 113287 Human
Unigene: 404697 Mouse
Unigene: 10705 Rat
Product Picture Sample: MCF-7 Cell (Human) Lysate at 40 ug
Primary: Anti-DLGAP2 (SL12139R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 118 kD
Observed band size: 118 kD
Tissue/cell: Rat brain tissue ; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-DLGAP2 Polyclonal Antibody, Unconjugated(SL12139R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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