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Product Name Striatin 4 Chinese Name STRN4蛋白抗体 Alias Striatin-4; STRN4; STRN4_HUMAN; ZIN; Zinedin. Research Area Cell biology Neurobiology Signal transduction Kinases and Phosphatases Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 80kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Striatin 4/zinedin: 85-190/753 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Striatin, SG2NA, and zinedin, the three mammalian members of the striatin family, are multimodular, WD-repeat and calmodulin-binding proteins. Zinedin and SG2NA share with striatin identical protein-protein interaction domains and the same overall domain structure. All three proteins are both cytosolic and membrane-bound and bind calmodulin in the presence of calcium. Striatin is a neuronal, intracellular protein strictly expressed in the somatodendritic compartment, including spines, subsets of neurons, and is considered as a marker of neuronal polarity. Downregulation of striatin, which is expressed in a few subsets of neurons, impairs the growth of dendrites as well as rat locomotor activity. Zinedin is mainly expressed in the central nervous system, whereas SG2NA is mainly expressed in the brain and muscle.
Function:
Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
Subcellular Location:
Cytoplasm. Membrane.
Similarity:
Belongs to the WD repeat striatin family.
Contains 7 WD repeats.
SWISS:
Q9NRL3
Gene ID:
29888
Database links:Entrez Gene: 29888 Human
Entrez Gene: 97387 Mouse
Omim: 614767 Human
SwissProt: Q9NRL3 Human
SwissProt: P58404 Mouse
Unigene: 631590 Human
Unigene: 21612 Mouse
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