Product Name	APXL
Chinese Name	APXL蛋白抗体
Alias	Apical like protein; Apical like protein APXL protein; apical protein of Xenopus-like; Apical protein Xenopus laevis like; apical protein, Xenopus laevis-like; apical protein-like; apical protein-like (Xenopus laevis); Apical-like protein; APX homolog of Xenopus; C630003H05Rik; DKFZp781J074; FLJ39277; HSAPXL; Liver regeneration-related protein LRRG167; Protein Apxl; Protein Shroom2; Shrm2; SHRM2_HUMAN; SHROOM 2; Shroom family member 2; shroom2.
Research Area	Cardiovascular  Neurobiology  Channel protein  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	176kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human APXL: 701-850/1616
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	APXL is a 1,616 amino acid protein that localizes to a variety of locations within the cell, including the cytoplasm, the cytoskeleton, the cell junction and the apical cell membrane. Containing one ASD1 domain, one ASD2 domain and one PDZ domain, APXL interacts with F-Actin and is thought to mediate endothelial cell morphology during cell spreading, possibly regulating melanosome biogenesis and inducing γ Tubulin redistribution. APXL is expressed in kidney, brain, lung, pancreas and placenta and is overexpressed in melanomas, suggesting a role in tumor transformation and metastasis. The gene encoding APXL maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination. There are a number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy. Function: May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution. Subunit: Interacts with F-actin (By similarity). Subcellular Location: Apical cell membrane (By similarity). Cell junction, tight junction (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associates with cortical F-actin (By similarity). Tissue Specificity: Abundant in retina and melanoma; also in brain, placenta, lung, kidney and pancreas. Similarity: Belongs to the shroom family. Contains 1 ASD1 domain. Contains 1 ASD2 domain. Contains 1 PDZ (DHR) domain. SWISS: Q13796 Gene ID: 357 Database links: Entrez Gene: 357 Human Entrez Gene: 110380 Mouse Entrez Gene: 317435 Rat Omim: 300103 Human SwissProt: Q13796 Human SwissProt: A2ALU4 Mouse SwissProt: Q7TP36 Rat Unigene: 567236 Human Unigene: 40796 Mouse Unigene: 16033 Rat

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