Product Name	ACCN4
Chinese Name	脑钠Channel protein4抗体
Alias	Accn4; ACCN4_HUMAN; Acid sensing (proton gated) ion channel family member 4; Acid sensing ion channel 4; Acid-sensing ion channel 4; Amiloride sensitive cation channel 4; Amiloride sensitive cation channel 4 pituitary; Amiloride sensitive cation channel family member 4 pituitary; Amiloride-sensitive cation channel 4; Amiloride-sensitive cation channel 4; ASIC4; BNAC4; Brain sodium channel 4; pituitary.
Research Area	Neurobiology  Channel protein  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	70kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ACCN4/ASIC4: 451-550/647 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]. Function: Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. Subunit: Homotrimer or heterotrimer with other ASIC proteins. Subcellular Location: .Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in pituitary gland. Weakly expressed in brain, vestibular system and organ of Corti. Similarity: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN4 subfamily. SWISS: Q96FT7 Gene ID: 55515 Database links: Entrez Gene: 55515 Human Entrez Gene: 241118 Mouse Entrez Gene: 63882 Rat Omim: 606715 Human SwissProt: Q96FT7 Human SwissProt: Q7TNS7 Mouse SwissProt: Q9JHS6 Rat Unigene: 87469 Human Unigene: 110790 Mouse Unigene: 44831 Rat

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