Product Name	SLC38A2
Chinese Name	氨基酸Transporter2抗体
Alias	Amino acid transporter 2; Amino acid transporter A2; ATA2; SNAT2; KIAA1382; PRO1068; Protein 40-9-1; S38A2_HUMAN; SAT2; Slc38a2; Sodium-coupled neutral amino acid transporter 2; Solute carrier family 38 member 2; System A amino acid transporter; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2.
literatures	Specific References  (3)     |     SL12125R has been referenced in 3 publications. [IF=16.174] Zhao Xiaohui. et al. Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A. NAT CHEM BIOL. 2023 May;:1-10  WB ;  Human.   PubMed:37248411 [IF=5.076] Hu C et al. Placentae for Low Birth Weight Piglets Are Vulnerable to Oxidative Stress, Mitochondrial Dysfunction, and Impaired Angiogenesis. Oxid Med Cell Longev. 2020 May 25;2020:8715412.  WB ;  Pig.   PubMed:32566107 [IF=3.478] Jan Remsik. et al. Characterization, isolation and in vitro culture of leptomeningeal fibroblasts. J Neuroimmunol. 2021 Sep;:577727  IF ;  mouse .   PubMed:34688068
Research Area	Neurobiology  Channel protein  The cell membrane受体  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	56kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SLC38A2/SNAT2: 21-150/506
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family include System A subtypes SNAT1, SNAT2 and SNAT4 and System N subtypes SNAT3 and SNAT5. The SLC38 transporters are essential for the uptake of nutrients, energy production, metabolism, detoxification, and the cycling of neurotransmitters. SNAT2, also designated ATA2, PRO1068 and SAT2 is encoded by the human gene SLC38A2. The functional role of SNAT2 in the nervous system is unclear. Protein expression is notably enriched in the spinal cord and brain stem nuclei of the auditory system. System A transport proteins are also present in placental tissue. These SNAT proteins may play a significant role in fetal development and inhibition of the transport system has been associated with fetal growth retardation. Function: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta. Subcellular Location: Cell membrane. Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. Tissue Specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level). Post-translational modifications: Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. Similarity: Belongs to the amino acid/polyamine transporter 2 family. SWISS: Q96QD8 Gene ID: 112483 Database links: Entrez Gene: 338044 Cow Entrez Gene: 54407 Human Entrez Gene: 67760 Mouse Entrez Gene: 29642 Rat Omim: 605180 Human SwissProt: Q96QD8 Human SwissProt: Q8CFE6 Mouse SwissProt: Q9JHE5 Rat Unigene: 221847 Human Unigene: 46754 Mouse Unigene: 16393 Rat
Product Picture	Sample: Lane 1: Mouse Liver tissue lysates Lane 2: Rat Lung tissue lysates Primary: Anti-SLC38A2 (SL12125R) at 1/200 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kDa Observed band size: 60 kDa Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SLC38A2) Polyclonal Antibody, Unconjugated (SL12125R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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