Product Name	Chromogranin C
Chinese Name	嗜铬粒蛋白C抗体
Alias	CHGC; Chromogranin-C; MEN1; SCG2; SCG2_HUMAN; Secretogranin II; Secretogranin-2; Secretoneurin; Secretoneurin included; SgII; SN.
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	68kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Chromogranin C/Sg II: 101-200/617
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A); chromogranin B (Chr-B), also known as secretogranin I; chromogranin C (also known as secretogranin II or Sg II); and secretogranin III (Sg III or SCG3). High levels of Chr-A expression are characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms; the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes. Function: Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. Subcellular Location: Secreted. Neuroendocrine and endocrine secretory granules. Tissue Specificity: Belongs to the chromogranin/secretogranin protein family. Similarity: Belongs to the chromogranin/secretogranin protein family. SWISS: P13521 Gene ID: 7857 Database links: Entrez Gene: 7857 Human Entrez Gene: 20254 Mouse Entrez Gene: 24765 Rat Omim: 118930 Human SwissProt: P13521 Human SwissProt: Q03517 Mouse SwissProt: P10362 Rat Unigene: 516726 Human Unigene: 5038 Mouse Unigene: 45602 Rat

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