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Product Name DNER Chinese Name 脑表皮生长因子Transmembrane proteinDNER抗体 Alias Brain EGF repeat-containing transmembrane protein; Bret; Delta and Notch-like epidermal growth factor-related receptor; Delta/notch-like EGF-related receptor; Dner; DNER_HUMAN; PRO299; Transmembrane protein Bet; UNQ26. Research Area Neurobiology Signal transduction Stem cells Cell Surface Molecule Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 75kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human DNER: 185-300/737 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.
Function:
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.
Subunit:
Interacts with AP1G1. Interacts with NOTCH1.
Subcellular Location:
Cell membrane. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region.
Tissue Specificity:
Expressed in brain, spinal cord and adrenal gland.
Similarity:
Contains 10 EGF-like domains.
Contains 1 follistatin-like domain.
SWISS:
Q8NFT8
Gene ID:
92737
Database links:Entrez Gene: 92737 Human
Entrez Gene: 227325 Mouse
Omim: 607299 Human
SwissProt: Q8NFT8 Human
SwissProt: Q8JZM4 Mouse
Unigene: 234074 Human
Unigene: 292560 Mouse
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