Product Name	P2X5b
Chinese Name	三磷酸腺苷受体P2X5b抗体
Alias	ATP receptor; ATP receptor subunit; ionotropic ATP receptor P2X5; MGC47755; P2RX5; P2X purinoceptor 5; P2X5; P2X5R; Purinergic receptor; Purinergic receptor P2X ligand gated ion channel 5; P2RX5_HUMAN.
Research Area	Neurobiology  Apoptosis  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	47kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human P2X5b: 261-360/422 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP. Function: P2X5b belongs to the family of purinoceptors for ATP. This receptor functions as a ligand gated ion channel. Several characteristic motifs of ATP gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene. Subunit: Functional P2XRs are organized as homomeric and heteromeric trimers Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed at high levels in brain and immune system. Similarity: Belongs to the P2X receptor family. SWISS: Q93086 Gene ID: 5026 Database links: Entrez Gene: 5026 Human Omim: 602836 Human SwissProt: Q8IXW4 Human SwissProt: Q93086 Human Unigene: 408615 Human
Product Picture	Sample: Raji Cell (Human) Lysate at 40 ug Primary: Anti-P2X5b (SL12109R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 50 kD Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-P2X5b (SL12109R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 50 kD Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti- P2X5b (SL12109R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47kD Observed band size: 51 kD Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti- P2X5b (SL12109R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47kD Observed band size: 51 kD

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